Padeken Lab
Research Publications Group Members Biography2024
Al-Refaie N, Padovani F, Hornung J, Pudelko L, Binando F, Del Carmen Fabregat A, Zhao Q, Towbin BD, Cenik ES, Stroustrup N, Padeken J, Schmoller KM and Cabianca DS ( 2024 ) Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis. Nat Cell Biol , 26:1903–1917 Link
Changiarath A, Flores-Solis D, Michels JJ, Rodriguez RH, Hanson SM, Schmid F, Zweckstetter M#, Padeken J# and Stelzl LS# ( 2024 ) Promoter and gene-body RNA-polymerase II co-exist in partial demixed condensates. bioRxiv , doi: 10.1101/2024.03.16.585180 (#indicates joint correspondence) Link
Changiarath Sivadasan A, Arya A, Xenidis VA, Padeken J and Stelzl LS ( 2024 ) Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning. Faraday Discuss , doi: 10.1039/D4FD00099D Link
Delaney CE, You JE, Gasser SM, Padeken J# and Mango SE# ( 2024 ) H3K9 methylation-independent activity for HPL-2/HP1 in heterochromatin foci, gene repression, and organogenesis. bioRxiv , doi: 10.1101/2024.09.29.615660 (#indicates joint correspondence) Link
2022
Delaney CE, Methot SP, Kalck V, Seebacher J, Hess D, Gasser SM and Padeken J (2022) SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity. Nat Struct Mol Biol, 29:85–96 Link
Padeken J, Methot SP and Gasser SM (2022) Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance. Nat Rev Mol Cell Biol, 23:623-640 Link
2021
Methot SP*, Padeken J*, Brancati G, Zeller P, Delaney CE, Gaidatzis D, Kohler H, van Oudenaarden A, Großhans H and Gasser SM (2021) H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Nat Cell Biol, 23:1163–1175 (*indicates joint contribution) Link
Padeken J, Methot S, Zeller P, Delaney CE, Kalck V and Gasser SM (2021) Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression. Genes Dev, 35:82–101 Link
2020
Harr JC, Schmid CD, Muñoz-Jiménez C, Romero-Bueno R, Kalck V, Gonzalez-Sandoval A, Hauer MH, Padeken J, Askjaer P, Mattout A and Gasser SM (2020) Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model. Genes Dev, 34:560–579 Link
Mattout A, Gaidatzis D, Padeken J, Schmid CD, Aeschimann F, Kalck V and Gasser SM (2020) LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Nat Cell Biol, 22:579–590 Link
2019
Cabianca DS, Muñoz-Jiménez C, Kalck V, Gaidatzis D, Padeken J, Seeber A, Askjaer P and Gasser SM (2019) Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei. Nature, 569:734–739 Link
Delaney CE*, Methot SP*, Guidi M*, Katic I, Gasser SM and Padeken J (2019) Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65. J Cell Biol, 218:820–838 (*indicates joint contribution) Link
Padeken J*, Zeller P*, Towbin B, Katic I, Kalck V, Methot SP and Gasser SM (2019) Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression. Genes Dev, 33:436–451 (*indicates joint contribution) Link
2016
Zeller P*, Padeken J*, van Schendel R, Kalck V, Tijsterman M and Gasser SM (2016) Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability. Nat Genet, 48:1385–1395 (*indicates joint contribution) Link
2015
Padeken J, Zeller P and Gasser SM (2015) Repeat DNA in genome organization and stability. Curr Opin Genet Dev, 31:12–19 Link
2014
Padeken J and Heun P (2014) Nucleolus and nuclear periphery: Velcro for heterochromatin. Curr Opin Cell Biol, 28:54–60 Link
2013
Padeken J and Heun P (2013) Centromeres in nuclear architecture. Cell Cycle, 12:3455–3456 Link
Padeken J, Mendiburo MJ, Chlamydas S, Schwarz HJ, Kremmer E and Heun P (2013) The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus. Mol Cell, 50:236–249 Link
Thomae AW, Schade GOM*, Padeken J*, Borath M, Vetter I, Kremmer E, Heun P and Imhof A (2013) A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Dev Cell, 27:412–424 (*indicates joint contribution) Link
2011
Mendiburo MJ, Padeken J, Fülöp S, Schepers A and Heun P (2011) Drosophila CENH3 is sufficient for centromere formation. Science, 334:686–690 Link