Padeken Lab
Research Publications Group Members Biography2024
Al-Refaie N, Padovani F, Hornung J, Pudelko L, Binando F, Del Carmen Fabregat A, Zhao Q, Towbin BD, Cenik ES, Stroustrup N, Padeken J, Schmoller KM and Cabianca DS (2024) Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis. Nat Cell Biol , 26:1903–1917 Link
Changiarath A, Flores-Solis D, Michels JJ, Rodriguez RH, Hanson SM, Schmid F, Zweckstetter M#, Padeken J# and Stelzl LS# (2024) Promoter and gene-body RNA-polymerase II co-exist in partial demixed condensates. bioRxiv , doi: 10.1101/2024.03.16.585180 (#indicates joint correspondence) Link
Changiarath Sivadasan A, Arya A, Xenidis VA, Padeken J and Stelzl LS (2024) Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning. Faraday Discuss , doi: 10.1039/D4FD00099D Link
Delaney CE, You JE, Gasser SM, Padeken J# and Mango SE# (2024) H3K9 methylation-independent activity for HPL-2/HP1 in heterochromatin foci, gene repression, and organogenesis. bioRxiv , doi: 10.1101/2024.09.29.615660 (#indicates joint correspondence) Link
2022
Delaney CE, Methot SP, Kalck V, Seebacher J, Hess D, Gasser SM and Padeken J (2022) SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity. Nat Struct Mol Biol, 29:85–96 Link
Padeken J, Methot SP and Gasser SM (2022) Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance. Nat Rev Mol Cell Biol, 23:623-640 Link
2021
Methot SP*, Padeken J*, Brancati G, Zeller P, Delaney CE, Gaidatzis D, Kohler H, van Oudenaarden A, Großhans H and Gasser SM (2021) H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Nat Cell Biol, 23:1163–1175 (*indicates joint contribution) Link
Padeken J, Methot S, Zeller P, Delaney CE, Kalck V and Gasser SM (2021) Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression. Genes Dev, 35:82–101 Link
2020
Harr JC, Schmid CD, Muñoz-Jiménez C, Romero-Bueno R, Kalck V, Gonzalez-Sandoval A, Hauer MH, Padeken J, Askjaer P, Mattout A and Gasser SM (2020) Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model. Genes Dev, 34:560–579 Link
Mattout A, Gaidatzis D, Padeken J, Schmid CD, Aeschimann F, Kalck V and Gasser SM (2020) LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Nat Cell Biol, 22:579–590 Link
2019
Cabianca DS, Muñoz-Jiménez C, Kalck V, Gaidatzis D, Padeken J, Seeber A, Askjaer P and Gasser SM (2019) Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei. Nature, 569:734–739 Link
Delaney CE*, Methot SP*, Guidi M*, Katic I, Gasser SM and Padeken J (2019) Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65. J Cell Biol, 218:820–838 (*indicates joint contribution) Link
Padeken J*, Zeller P*, Towbin B, Katic I, Kalck V, Methot SP and Gasser SM (2019) Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression. Genes Dev, 33:436–451 (*indicates joint contribution) Link
2016
Zeller P*, Padeken J*, van Schendel R, Kalck V, Tijsterman M and Gasser SM (2016) Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability. Nat Genet, 48:1385–1395 (*indicates joint contribution) Link
2015
Padeken J, Zeller P and Gasser SM (2015) Repeat DNA in genome organization and stability. Curr Opin Genet Dev, 31:12–19 Link
2014
Padeken J and Heun P (2014) Nucleolus and nuclear periphery: Velcro for heterochromatin. Curr Opin Cell Biol, 28:54–60 Link
2013
Padeken J and Heun P (2013) Centromeres in nuclear architecture. Cell Cycle, 12:3455–3456 Link
Padeken J, Mendiburo MJ, Chlamydas S, Schwarz HJ, Kremmer E and Heun P (2013) The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus. Mol Cell, 50:236–249 Link
Thomae AW, Schade GOM*, Padeken J*, Borath M, Vetter I, Kremmer E, Heun P and Imhof A (2013) A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Dev Cell, 27:412–424 (*indicates joint contribution) Link
2011
Mendiburo MJ, Padeken J, Fülöp S, Schepers A and Heun P (2011) Drosophila CENH3 is sufficient for centromere formation. Science, 334:686–690 Link