RNA carries out many important roles in the cell: messenger RNAs encode information for protein production, while non-coding RNAs have multiple roles, ranging from gene regulation to the maintenance of DNA integrity. These functions are essential for development, fertility, and cell survival. At IMB, we study the biology of RNAs from transcription to processing and maturation, and interrogate the role that RNA plays in gene regulation and genome integrity to better understand development, reproduction and disease.
Key techniques used: RNA-seq, DRIP-seq, RNAi, in-situ fluorescence microscopy, chromatin immunoprecipitation (ChIP), individual-nucleotide resolution UV crosslinking and immunoprecipitation (iCLIP), bioinformatics.
Keywords: RNA modifications, epigenetics, small RNAs, Argonaute, ribosome, non-coding RNA, DNA methylation, antisense, telomeres, germline, R-loops.