Biology of Non-coding RNA

Figure 3. Subcellular localization of the piRNA pathway.
Nuage (green) and P-bodies (yellow) have been observed to interact in multiple systems, which may result in the exchange of proteins and RNA molecules. Many AGO proteins are found within P-bodies or nuage. Some of these interactions are mediated via the binding of Tudor-domain-containing proteins (Tdrd; blue and light purple) to methylated arginine residues in AGO proteins (most notable Piwi proteins). AGO proteins associated with nuage and P-bodies can be involved directly in the silencing of target RNA molecules. Upon sRNA loading, some AGO proteins can also translocate into the nucleus through the nuclear pore (purple). Nuclear AGO proteins can affect gene expression by modulating DNA methylation (-Me) and histone (red) modification (-X), as well as RNA polymerase II (green) transcription elongation activity.
From: Ketting, Developmental Cell, 2011